Norepinephrine is a catecholamine which acts as both a hormone and a neurotransmitter. Research is currently exploring whether norepinephrine may play a role in maintaining restriction in anorexia nervosa. Norepinephrine regulation has been implicated in both depression and anxiety in association with eating disorders.  It influences appetite at the hypothalamic level. Starvation decreases norepinephrine synthesis resulting in lowered appetite and lower BMR. The lowered metabolism may protect patients by decreasing their nutritional requirements. As a stress hormone, along with epinephrine, norepinephrine also underlies the fight-or-flight response. When norepinephrine acts as a drug it increases blood pressure, thereby heightening the risk of reflex bradycardiaSource.

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