Tricyclic antidepressants (TCAs)

Tricyclic antidepressants, or TCAs, were the first class of drugs developed to treat depression, and have have been shown to reduce binge eating and vomiting in the treatment of bulimia nervosa.  TCAs inhibit the reabsorption (reuptake) of serotonin and norepinephrine. To a lesser extent, TCAs also inhibit reabsorption of dopamine. Side affects are thought to be due to their wider blocking impact on other brain receptors. When TCAs are administered, it is necessary to be alert to potential adverse interactions with certain foods and/or other medications the patient is receiving.  Additional information.

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